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Hemagglutinin and neuraminidase of a non-pathogenic H7N7 avian influenza virus coevolved during the acquisition of intranasal pathogenicity in chickens.

Archives of virology - 22 Sept 2024

Ichikawa Takaya, Hiono Takahiro, Okamatsu Masatoshi, Maruyama Junki, Kobayashi Daiki, Matsuno Keita, Kida Hiroshi, Sakoda Yoshihiro

Abstract excerpt

Polybasic amino acid residues at the hemagglutinin (HA) cleavage site are insufficient to induce the highly pathogenic phenotype of avian influenza viruses in chickens. In our previous study, an H7N7 avian influenza virus named "Vac2sub-P0", which is nonpathogenic despite carrying polybasic amino acids at the HA cleavage site, was passaged in chick air sacs, and a virus with high intravenous pathogenicity,...

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Identifiers

PMID: 39307848
DOI: 10.1007/s00705-024-06118-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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