Article

Hemagglutinin and neuraminidase of an H7N7 non-pathogenic avian influenza virus coevolved during the acquisition of intranasal pathogenicity in chickens

2024-04-03

Abstract excerpt

<title>Abstract</title> <p>Polybasic amino acid residues at the hemagglutinin (HA) cleavage site are insufficient to induce the highly pathogenic phenotype of avian influenza viruses in chickens. In our previous study, an H7N7 avian influenza virus named Vac2sub-P0, which is non-pathogenic despite carrying polybasic amino acids at the HA cleavage site, was passaged in chick air sacs and a virus with high intraven...

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Literature Corpus work: e09b285f-d8b9-55c2-ab61-23f387cfb922
DOI: 10.21203/rs.3.rs-4161114/v1

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