Article
The Emergence of H7N7 Highly Pathogenic Avian Influenza Virus from Low Pathogenicity Avian Influenza Virus Using an in ovo Embryo Culture Model.
Viruses - 21 Aug 2020
Seekings Amanda H, Howard Wendy A, Nuñéz Alejandro, Slomka Marek J, Banyard Ashley C, Hicks Daniel, Ellis Richard J, Nuñéz-García Javier, Hartgroves Lorian C, Barclay Wendy S, Banks Jill, Brown Ian H
Abstract excerpt
Outbreaks of highly pathogenic avian influenza virus (HPAIV) often result in the infection of millions of poultry, causing up to 100% mortality. HPAIV has been shown to emerge from low pathogenicity avian influenza virus (LPAIV) in field outbreaks. Direct evidence for the emergence of H7N7 HPAIV from a LPAIV precursor with a rare di-basic cleavage site (DBCS) was identified in the UK in 2008. The DBCS contained...
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