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Article

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

12 Sept 2011

Abstract excerpt

Primary tumors facilitate metastasis by directing bone marrow-derived cells (BMDCs) to colonize the lungs before the arrival of cancer cells. Here, we demonstrate that hypoxia-inducible factor 1 (HIF-1) is a critical regulator of breast cancer metastatic niche formation through induction of multiple members of the lysyl oxidase (LOX) family, including LOX, LOX-like 2, and LOX-like 4, which catalyze collagen...

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PMID: 21911388
DOI: 10.1073/pnas.1113483108

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