Article

Novel mechanism for OSM-promoted extracellular matrix remodeling in breast cancer: LOXL2 upregulation and subsequent ECM alignment

2020-08-12

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Invasive ductal carcinoma (IDC) is a serious problem for patients as it metastasizes, decreasing 5-year patient survival from >95% to ~27%. The breast tumor microenvironment (TME) is often saturated with proinflammatory cytokines, such as oncostatin M (OSM), which promote epithelial-to-mesenchymal transitions (EMT) in IDC and increased metastasis. The extracellu...

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Literature Corpus work: 01e546b1-ce14-54e7-995e-c266742abda9
DOI: 10.21203/rs.3.rs-57684/v1

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