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Article

HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer

1 Sept 2020

Abstract excerpt

Hypoxia-inducible factors (HIFs) and the HIF-dependent cancer hallmarks angiogenesis and metabolic rewiring are well-established drivers of breast cancer aggressiveness, therapy resistance, and poor prognosis. Targeting of HIF and its downstream targets in angiogenesis and metabolism has been unsuccessful so far in the breast cancer clinical setting, with major unresolved challenges residing in target selection,...

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PMID: 32870818
DOI: 10.1172/jci137552

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