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Article

Regulation of chromosomal replication initiation by oriC-proximal DnaA-box clusters in Bacillus subtilis.

Nucleic acids research - 1 Jan 2012

Okumura Hajime, Yoshimura Mika, Ueki Mikako, Oshima Taku, Ogasawara Naotake, Ishikawa Shu

Abstract excerpt

Bacterial chromosome replication is initiated by binding of DnaA to a DnaA-box cluster (DBC) within the replication origin (oriC). In Bacillus subtilis, six additional DBCs are found outside of oriC and some are known to be involved in transcriptional regulation of neighboring genes. A deletion mutant lacking the six DBCs (Δ6) initiated replication early. Further, inactivation of spo0J in Δ6 cells yielded a...

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Identifiers

PMID: 21911367
DOI: 10.1093/nar/gkr716
PMCID: PMC3245932

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of chromosomal replication initiation by oriC-proximal DnaA-box clusters in Bacillus subtilis.PMID 21911367Read ↗

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