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Article

Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: one step forward, and one step back?

Radiation oncology (London, England) - 13 Sept 2011

Combs Stephanie E, Rieken Stefan, Wick Wolfgang, Abdollahi Amir, von Deimling Andreas, Debus Jürgen, Hartmann Christian

Abstract excerpt

A group of 160 patients with primary glioblastoma treated with radiotherapy and temozolomide was analyzed for the impact of O6-methly-guanly-methyl-transferase (MGMT)-promoter methylation as well as isocitrate dehydrogenase (IDH)1-mutational status. Unexpectedly, overall survival or progression-free survival were not longer in the group with methylated MGMT-promoter as compared to patients without that...

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Identifiers

PMID: 21910919
DOI: 10.1186/1748-717X-6-115
PMCID: PMC3199258

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: one step forward, and one step back?PMID 21910919Read ↗

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