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Article

Recent advances in the molecular understanding of glioblastoma.

Journal of neuro-oncology - 1 May 2012

Bleeker Fonnet E, Molenaar Remco J, Leenstra Sieger

Abstract excerpt

Glioblastoma is the most common and most aggressive primary brain tumor. Despite maximum treatment, patients only have a median survival time of 15 months, because of the tumor's resistance to current therapeutic approaches. Thus far, methylation of the O (6)-methylguanine-DNA methyltransferase (MGMT) promoter has been the only confirmed molecular predictive factor in glioblastoma. Novel "genome-wide" techniques...

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Topics

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Share to Central Nervous System Neoplasms
Share to Epigenesis, Genetic
Share to IDH1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glioma Diagnosis and Treatment

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Source

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Identifiers

PMID: 22270850
DOI: 10.1007/s11060-011-0793-0
PMCID: PMC3337398

Genes

IDH1
MGMT

Provenance

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