Article
The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone.
Neuro-oncology - 1 Sept 2014
Molenaar Remco J, Verbaan Dagmar, Lamba Simona, Zanon Carlo, Jeuken Judith W M, Boots-Sprenger Sandra H E, Wesseling Pieter, Hulsebos Theo J M, Troost Dirk, van Tilborg Angela A, Leenstra Sieger, Vandertop W Peter, Bardelli Alberto, van Noorden Cornelis J F, Bleeker Fonnet E
Abstract excerpt
BACKGROUND: Genetic and epigenetic profiling of glioblastomas has provided a comprehensive list of altered cancer genes of which only O(6)-methylguanine-methyltransferase (MGMT) methylation is used thus far as a predictive marker in a clinical setting. We investigated the prognostic significance of genetic and epigenetic alterations in glioblastoma patients. METHODS: We screened 98 human glioblastoma samples for...
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