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Article

Personalized treatment strategies in glioblastoma: MGMT promoter methylation status

1 Sept 2013

Abstract excerpt

The identification of molecular genetic biomarkers considerably increased our current understanding of glioma genesis, prognostic evaluation, and treatment planning. In glioblastoma, the most malignant intrinsic brain tumor entity in adults, the promoter methylation status of the gene encoding for the repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) indicates increased efficacy of current standard of...

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Share to Epigenetics and DNA Methylation
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PMID: 24109190
DOI: 10.2147/ott.s50208

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