Article
Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2012
Ray Lara A, Bujarski Spencer, Chin Pauline F, Miotto Karen
Abstract excerpt
Recent clinical and laboratory studies have shown that the effects of naltrexone for alcoholism may be moderated by the Asn40Asp single-nucleotide polymorphism (SNP) of the μ-opioid receptor gene (OPRM1). Allele frequencies for this polymorphism, however, have been shown to vary substantially as a function of ethnic background, such that individuals of Asian descent are more likely to carry the minor (Asp40)...
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