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Article

Naltrexone selectively elevates GABAergic neuroactive steroid levels in heavy drinkers with the Asp40 allele of the OPRM1 gene: a pilot investigation.

Alcoholism, clinical and experimental research - 1 Aug 2010

Ray Lara A, Hutchison Kent E, Ashenhurst James R, Morrow A Leslie

Abstract excerpt

BACKGROUND: Preclinical studies have implicated GABAergic neurosteroids in behavioral responses to alcohol. Naltrexone is thought to blunt the reinforcing effects of alcohol, and a few studies have found that the effects of naltrexone are moderated by the Asn40Asp polymorphisms of the OPRM1 gene....

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Source

Identifiers

PMID: 20528823
DOI: 10.1111/j.1530-0277.2010.01233.x

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20528823-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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