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Article

Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers.

Alcoholism, clinical and experimental research - 1 Jul 2008

Arias Albert J, Armeli Stephen, Gelernter Joel, Covault Jonathan, Kallio Antero, Karhuvaara Sakari, Koivisto Tiina, Mäkelä Rauno, Kranzler Henry R

Abstract excerpt

BACKGROUND: Recent studies examining the moderating effects of polymorphic variation in opioid receptor genes have yielded conflicting results. We examined opioid receptor gene polymorphisms as moderators of the therapeutic effects of the opioid antagonist nalmefene. METHODS: Participants (n = 272) were subjects who consented to the pharmacogenetic analysis of a multi-site, randomized, placebo-controlled trial of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18537939
DOI: 10.1111/j.1530-0277.2008.00735.x
PMCID: PMC2950972

Genes

OPRM1
OPRD1
OPRK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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