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Article

A review of the existing pharmacogenomic literature of naltrexone for use in alcohol use disorder.

Pharmacogenomics - 1 Jan 2025

Counts Christopher, Ali Nisha, Ali Syed, Muhammad Kafilah A, Diop Fatoumata B, Sims Keith, Ajoku Amarachukwu, Santos Cynthia

Abstract excerpt

Naltrexone is an opioid receptor antagonist used to treat alcohol use disorder; however, like other commonly used addiction treatment options, it demonstrates inconsistency in treatment response. Pharmacogenomics may be used to individualize addiction treatment and identify patients who would be better candidates for this drug. Recently, the Clinical Pharmacogenomics Implementation Consortium (CPIC) provided...

Topics

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Alcohol Dehydrogenase
Alcoholism
Aldehyde Dehydrogenase
Naltrexone
Narcotic Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharmacogenetics

Polymorphism, Single Nucleotide

Receptors, Opioid, mu

Source

Open in PubMed Open full text

Identifiers

PMID: 41553151
DOI: 10.1080/14622416.2026.2613634
PMCID: PMC12915813

Genes

OPRM1
ADH1B
ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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