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Article

SMAD7 antagonizes key TGFβ superfamily signaling in mouse granulosa cells in vitro

1 May 2013

Abstract excerpt

Transforming growth factor β (TGFβ) superfamily signaling is essential for female reproduction. Dysregulation of the TGFβ signaling pathway can cause reproductive diseases. SMA and MAD (mothers against decapentaplegic) (SMAD) proteins are downstream signaling transducers of the TGFβ superfamily. SMAD7 is an inhibitory SMAD that regulates TGFβ signaling in vitro. However, the function of SMAD7 in the ovary remains...

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PMID: 23633623
DOI: 10.1530/rep-13-0093

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