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Article

Integral role of GDF-9 and BMP-15 in ovarian function.

Molecular reproduction and development - 1 Jan 2011

Otsuka Fumio, McTavish Kirsten J, Shimasaki Shunichi

Abstract excerpt

The oocyte plays an important role in regulating and promoting follicle growth, and thereby its own development, by the production of oocyte growth factors that predominantly act on supporting granulosa cells via paracrine signaling. Genetic studies in mice demonstrated critical roles of two key oocyte-derived growth factors belonging to the transforming growth factor-β (TGF-β) superfamily, growth and...

Topics

Animals
Bone Morphogenetic Protein 15
Disease Models, Animal
Female
Fertility
Granulosa Cells
Growth Differentiation Factor 9
Humans
Mice
Mutation
Oocytes
Primary Ovarian Insufficiency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sheep

Source

Open in PubMed Open full text

Identifiers

PMID: 21226076
DOI: 10.1002/mrd.21265
PMCID: PMC3051839

Genes

BMP15
GDF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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