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Does Bone Morphogenetic Protein 6 (BMP6) Affect Female Fertility in the Mouse?1

11 Aug 2010

Abstract excerpt

Bone morphogenetic protein 6 (BMP6) is a transforming growth factor beta superfamily member produced by mammalian oocytes as well as other cell types. Despite well-characterized effects of recombinant BMP6 on granulosa cells in vitro, the function of BMP6 in vivo has been ill-defined. Therefore, the effects of genetic deletion of the Bmp6 gene on female mouse fertility were assessed. The mean litter size of...

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PMID: 20702851
DOI: 10.1095/biolreprod.110.086777

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