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Article

Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Sept 2011

Peng Changgeng, Aron Liviu, Klein Rüdiger, Li Meng, Wurst Wolfgang, Prakash Nilima, Le Weidong

Abstract excerpt

Pitx3 is a critical homeodomain transcription factor for the proper development and survival of mesodiencephalic dopaminergic (mdDA) neurons in mammals. Several variants of this gene have been associated with human Parkinson's disease (PD), and lack of Pitx3 in mice causes the preferential loss of substantia nigra pars compacta (SNc) mdDA neurons that are most affected in PD. It is currently unclear how Pitx3...

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Identifiers

PMID: 21900559
DOI: 10.1523/JNEUROSCI.0898-11.2011
PMCID: PMC6623418

Genes

BDNF
GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons.PMID 21900559Read ↗

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