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Article

Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1.

Genesis (New York, N.Y. : 2000) - 1 Feb 2012

Berquam-Vrieze Katherine E, Swing Deborah A, Tessarollo Lino, Dupuy Adam J

Abstract excerpt

The Notch1 receptor plays a critical role in cell fate decisions during development. Activation of Notch signaling has been implicated in several types of cancer, particularly T-cell acute lymphoblastic leukemia (T-ALL). Consequently, several transgenic mouse strains have been made to study the role of Notch1 in T-ALL. However, the existing Notch1 transgenic lines mimic a translocation event found in only ∼1% of...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21898766
DOI: 10.1002/dvg.20798
PMCID: PMC3682665

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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