Article
Association of interleukin 28B and mutations in the core and NS5A region of hepatitis C virus with response to peg-interferon and ribavirin therapy.
Liver international : official journal of the International Association for the Study of the Liver - 1 Oct 2011
Hayashi Kazuhiko, Katano Yoshiaki, Honda Takashi, Ishigami Masatoshi, Itoh Akihiro, Hirooka Yoshiki, Ishikawa Tetsuya, Nakano Isao, Yoshioka Kentaro, Toyoda Hidenori, Kumada Takashi, Goto Hidemi
Abstract excerpt
BACKGROUND AND AIMS: Mutations in the core and NS5A region of hepatitis C virus (HCV) genotype 1b have been associated with response to interferon (IFN) therapy. Genome-wide association studies have revealed that the single-nucleotide polymorphism (SNP) of interleukin 28B (IL28B) contributes to IFN response. The aim of this study was to investigate whether the SNP of IL28B (rs8099917) and amino acid substitutions...
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