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Article

Isolation and characterization of new Saccharomyces cerevisiae mutants perturbed in nuclear pore complex assembly.

BMC genetics - 5 Sept 2002

Ryan Kathryn J, Wente Susan R

Abstract excerpt

BACKGROUND: Nuclear pore complexes (NPCs) are essential for facilitated, directional nuclear transport; however, the mechanism by which ~30 different nucleoporins (nups) are assembled into NPCs is unknown. We combined a genetic strategy in Saccharomyces cerevisiae with Green Fluorescence Protein (GFP) technology to identify mutants in NPC structure, assembly, and localization. To identify such mutants, a bank of...

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Identifiers

PMID: 12215173
DOI: 10.1186/1471-2156-3-17
PMCID: PMC126250

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