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Article

HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.

PloS one - 1 Jan 2011

Mangino Giorgio, Percario Zulema A, Fiorucci Gianna, Vaccari Gabriele, Acconcia Filippo, Chiarabelli Cristiano, Leone Stefano, Noto Alessia, Horenkamp Florian A, Manrique Santiago, Romeo Giovanna, Polticelli Fabio, Geyer Matthias, Affabris Elisabetta

Abstract excerpt

BACKGROUND: HIV-1 Nef is a virulence factor that plays multiple roles during HIV replication. Recently, it has been described that Nef intersects the CD40 signalling in macrophages, leading to modification in the pattern of secreted factors that appear able to recruit, activate and render T lymphocytes susceptible to HIV infection. The engagement of CD40 by CD40L induces the activation of different signalling...

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Source

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Identifiers

PMID: 21886773
DOI: 10.1371/journal.pone.0022982
PMCID: PMC3160284

Genes

TRAF2
STAT1
TRAF6
STAT2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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