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Modulation in the Gene Expression Profile of Astrocytes and Monocytes by HIV-1 Nef Variants

2022-02-21

Abstract excerpt

HIV-1 Nef is a multifunctional protein with well-known lethal properties. HIV infects various cells from the brain compartment and expressed nef is responsible for developing neuropathogenic potential. HIV-infected glial cells express nefvirotoxinand stimulate the cascade of various pathways to activate uninfected cells to release neurotoxic elements damaging cells themselves. A lot of genetic variabilities of thi...

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Literature Corpus work
0acceb3b-ee15-57d6-92e6-43e7ca8057e4
DOI
10.20944/preprints202202.0249.v1
Open publication

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Modulation in the Gene Expression Profile of Astrocytes and Monocytes by HIV-1 Nef VariantsDOI 10.20944/preprints202202.0249.v1
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