Article

Molecular characterization reveals subclasses of 1q gain in intermediate-risk Wilms tumors

2022-08-15

Abstract excerpt

<h4>Summary</h4> Chromosomal alterations have recurrently been identified in Wilms tumors (WTs) and some are associated with poor prognosis. Gain of 1q (1q+) is of special interest given its high prevalence and is currently actively studied for its prognostic value. However, the underlying mutational mechanisms and functional effects remain unknown. For 30 primary WTs, we integrated somatic SNVs, CNs and SVs with...

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Literature Corpus work: 454f2036-2316-5bcc-9cf5-fcd0952563c0
DOI: 10.1101/2022.08.12.503742

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