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Article

Failure of pharmacogenetic-based dosing algorithms to identify older patients requiring low daily doses of warfarin.

Journal of the American Medical Directors Association - 1 Nov 2011

Schwartz Janice B, Kane Lynn, Moore Kelly, Wu Alan H B

Abstract excerpt

INTRODUCTION: Warfarin doses vary greatly among patients and warfarin administration is accompanied by risk of bleeding. Genes responsible for its metabolism (CYP2C9) and effect on clotting (VKORC1) have been identified. It has been suggested that genotyping for variants in these genes can improve warfarin dosing and decrease bleeding complications. We evaluated performance of pharmacogenetic-based warfarin...

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Source

Identifiers

PMID: 21450231
DOI: 10.1016/j.jamda.2010.12.006

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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