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Article

Personalized Anticoagulation: Optimizing Warfarin Management Using Genetics and Simulated Clinical Trials.

Circulation. Cardiovascular genetics - 1 Dec 2017

Ravvaz Kourosh, Weissert John A, Ruff Christian T, Chi Chih-Lin, Tonellato Peter J

Abstract excerpt

BACKGROUND: Clinical trials testing pharmacogenomic-guided warfarin dosing for patients with atrial fibrillation have demonstrated conflicting results. Non-vitamin K antagonist oral anticoagulants are expensive and contraindicated for several conditions. A strategy optimizing anticoagulant selection remains an unmet clinical need. METHODS AND RESULTS: Characteristics from 14 206 patients with atrial fibrillation...

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Identifiers

PMID: 29237680
DOI: 10.1161/CIRCGENETICS.117.001804
PMCID: PMC5734112

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