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Article

Transformation of chicken embryo fibroblast cells by avian retroviruses containing the human Fyn gene and its mutated genes.

Molecular and cellular biology - 1 Jun 1990

Semba K, Kawai S, Matsuzawa Y, Yamanashi Y, Nishizawa M, Toyoshima K

Abstract excerpt

The transforming activity of the human fyn protein, p59fyn, which is a kinase of the src family, was investigated by testing the effect of recombinant avian retrovirus (Fyn virus) expressing p59fyn on chickens or cultured chicken embryo fibroblast (CEF) cells. The Fyn virus did not induce transformed foci. After several passages of the virus stock on CEF cells, however, a few foci were detected in the presence of...

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Identifiers

PMID: 2188108
DOI: 10.1128/mcb.10.6.3095-3104.1990
PMCID: PMC360674

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