Article
Transformation of chicken embryo fibroblast cells by avian retroviruses containing the human Fyn gene and its mutated genes.
Molecular and cellular biology - 1 Jun 1990
Semba K, Kawai S, Matsuzawa Y, Yamanashi Y, Nishizawa M, Toyoshima K
Abstract excerpt
The transforming activity of the human fyn protein, p59fyn, which is a kinase of the src family, was investigated by testing the effect of recombinant avian retrovirus (Fyn virus) expressing p59fyn on chickens or cultured chicken embryo fibroblast (CEF) cells. The Fyn virus did not induce transfo...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Transformation, Neoplastic
- Chick Embryo
- Dimethyl Sulfoxide
- Fibroblasts
- Genetic Vectors
- Humans
- Molecular Sequence Data
- Mutation
- Oncogenes
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-fyn