Direct transformation of rodent fibroblasts by jaagsiekte sheep retrovirus DNA

doi:10.1073/pnas.071547598

Article

Direct transformation of rodent fibroblasts by jaagsiekte sheep retrovirus DNA

10 Apr 2001

Abstract excerpt

Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary carcinoma, a unique animal model for human bronchioalveolar carcinoma. We previously isolated a JSRV proviral clone and showed that it was both infectious and oncogenic. Thus JSRV is necessary and sufficient for the development of ovine pulmonary carcinoma, but no data are available on the mechanisms of transformation. Inspection of the...

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