Article
Retroviruses that express different ras mutants cause different types of tumors in chickens.
Oncogene - 1 Jan 1992
Givol I, Greenhouse J J, Hughes S H, Ewert D L
Abstract excerpt
We have used replication-competent retroviral vectors to express avian and murine ras genes in cultured chick embryo fibroblasts (CEF) and in chickens. Since the viral vectors are identical, it is possible to compare the oncogenic potential of the ras genes directly. The normal (12 gly) form of c...
Topics
- Animals
- Bone Neoplasms
- Cell Transformation, Viral
- Chickens
- Genes, ras
- Lung Neoplasms
- Muscular Diseases
- Mutation
- Neoplasms, Experimental
- Retroviridae
- Transfection