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Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia

1 Sept 2011

Abstract excerpt

To evaluate the prognostic value of genetic mutations for acute myeloid leukemia (AML) patients, we examined the gene status for both fusion products such as AML1 (CBFα)-ETO, CBFβ-MYH11, PML-RARα, and MLL rearrangement as a result of chromosomal translocations and mutations in genes including FLT3, C-KIT, N-RAS, NPM1, CEBPA, WT1, ASXL1, DNMT3A, MLL, IDH1, IDH2, and TET2 in 1185 AML patients. Clinical analysis was...

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PMID: 21881046
DOI: 10.1182/blood-2011-03-343988

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