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Article

Mutation patterns of 16 genes in primary and secondary acute myeloid leukemia (AML) with normal cytogenetics.

PloS one - 1 Jan 2012

Fernandez-Mercado Marta, Yip Bon Ham, Pellagatti Andrea, Davies Carwyn, Larrayoz María José, Kondo Toshinori, Pérez Cristina, Killick Sally, McDonald Emma-Jane, Odero María Dolores, Agirre Xabier, Prósper Felipe, Calasanz María José, Wainscoat James S, Boultwood Jacqueline

Abstract excerpt

Acute myeloid leukemia patients with normal cytogenetics (CN-AML) account for almost half of AML cases. We aimed to study the frequency and relationship of a wide range of genes previously reported as mutated in AML (ASXL1, NPM1, FLT3, TET2, IDH1/2, RUNX1, DNMT3A, NRAS, JAK2, WT1, CBL, SF3B1, TP53, KRAS and MPL) in a series of 84 CN-AML cases. The most frequently mutated genes in primary cases were NPM1 (60.8%)...

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Source

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Identifiers

PMID: 22912701
DOI: 10.1371/journal.pone.0042334
PMCID: PMC3415392

Genes

ASXL1
TET2
FLT3
IDH1
NPM1
RUNX1
CBL
DNMT3A
JAK2
KRAS
MPL
NRAS
SF3B1
TP53
WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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