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[Analysis of Genomic Landscape in Patients with Acute Myeloid Leukemia].

Zhongguo shi yan xue ye xue za zhi - 1 Jun 2020

Wang Sheng-Mei, Zheng Hong-Jun, Tian Ying, Zhang Jian-Mei, Yao Jin-Hua

Abstract excerpt

OBJECTIVE: To investigate the gene mutation occurved in AML patients with 29 kinds of fusion genes and 51 kinds of tumor gene. METHODS: Next-generation sequencing (NGS) was used to detected the 49 kinds of targeted gene. FLT3 internal tandem duplication (FLT3-ITD), CALR, NPM1 and CEBPA mutation were detected by DNA-based PCR and Sanger sequencing. Twenty-nine kinds of fusion genes were dected by multiplex nested...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32552938
DOI: 10.19746/j.cnki.issn.1009-2137.2020.03.013

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