Article
Impact of genetic polymorphisms near the IL28B gene and amino acid substitutions in the hepatitis C virus core region on interferon sensitivity/resistance in patients with chronic hepatitis C.
Journal of medical virology - 1 Jul 2011
Toyoda Hidenori, Kumada Takashi, Tada Toshifumi, Kawaguchi Takahisa, Murakami Yoshiki, Matsuda Fumihiko
Abstract excerpt
It has been reported that genetic polymorphisms near the IL28B gene or amino acid substitutions in hepatitis C virus (HCV) core protein are associated with the clinical outcome of peginterferon (PEG-IFN) and ribavirin combination therapy. The impact of these factors on the pure sensitivity/resistance to interferon was evaluated. Changes in the HCV RNA levels 24, 48, 72, and 120 hr after administering a single...
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