Article
Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response.
Journal of viral hepatitis - 1 May 2012
Clark P J, Thompson A J, Zhu M, Vock D M, Zhu Q, Ge D, Patel K, Harrison S A, Urban T J, Naggie S, Fellay J, Tillmann H L, Shianna K, Noviello S, Pedicone L D, Esteban R, Kwo P, Sulkowski M S, Afdhal N, Albrecht J K, Goldstein D B, McHutchison J G, Muir A J
Abstract excerpt
Low-density lipoprotein cholesterol (LDL-C) levels and interleukin 28B (IL28B) polymorphism are associated with sustained viral response (SVR) to peginterferon/ribavirin (pegIFN/RBV) for chronic hepatitis C (CHC) infection. IL28B has been linked with LDL-C levels using a candidate gene approach, but it is not known whether other genetic variants are associated with LDL-C, nor how these factors definitively affect...
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