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Article

Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood

30 Aug 2011

Abstract excerpt

BACKGROUND: Peptidylarginine deiminase 2 (PAD2) and peptidylarginine deiminase 4 (PAD4) are two members of PAD family which are over-expressed in the multiple sclerosis (MS) brain. Through its enzymatic activity PAD2 converts myelin basic protein (MBP) arginines into citrullines - an event that may favour autoimmunity - while peptidylarginine deiminase 4 (PAD4) is involved in chromatin remodelling. OBJECTIVES:...

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PMID: 21878453
DOI: 10.1177/1352458511421055

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