Article
PADI4 gene in multiple sclerosis: a family-based association study.
Journal of neuroimmunology - 1 Aug 2006
Tommasi C, Petit-Teixeira E, Cournu-Rebeix I, Caponi L, Pierlot C, Fontaine B, Cornelis F, Migliorini P
Abstract excerpt
In multiple sclerosis (MS) MBP is heavily citrullinated by peptidylarginine deiminase (PAD). This post-translational modification may be crucial for its pathogenesis. PADI4 is the isoform expressed in inflammatory infiltrates. The aim of this study was to analyse the role of PADI4 gene in conferring susceptibility to MS, by means of a family-based association study, testing three SNPs by RFLP. No association was...
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