Article
Expression of CD44 confers a new adhesive phenotype on transfected cells.
Cell - 12 Jan 1990
St John T, Meyer J, Idzerda R, Gallatin W M
Abstract excerpt
The function of the CD44 glycoprotein as an adhesion molecule was directly tested by transformation of a CD44 cDNA into mouse fibroblasts. This cDNA was expressed as a heavily modified cell surface protein reactive with monoclonal antibodies that recognize glycoproteins now identified in primates as CD44. Independent transfectants exhibited a new self-adhesive phenotype, forming large aggregates when placed in...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Differentiation
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Aggregation
- L Cells
- Mice
- Papio
- Phenotype
- Plasmids
- Receptors, Lymphocyte Homing