Article
Pertussis toxin inhibition of T-cell hybridoma invasion is reversed by manganese-induced activation of LFA-1.
Journal of cell science - 1 Mar 1994
La Rivière G, Klein Gebbinck J W, Driessens M H, Roos E
Abstract excerpt
Pertussis toxin (PT) inhibits invasiveness of T-cell hybridomas in vitro and metastasis formation in vivo. We present evidence for the hypothesis that PT interferes with functional activation of LFA-1. Invasion by TAM2D2 T-cell hybridoma cells of fibroblast monolayers was completely blocked by PT...
Topics
- Animals
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Movement
- Culture Media, Serum-Free
- Fluorescent Antibody Technique
- Hybridomas
- Intercellular Adhesion Molecule-1
- Lymphocyte Function-Associated Antigen-1
- Manganese
- Mice
- Mutation
- Neoplasm Invasiveness
- Pertussis Toxin
- T-Lymphocytes
- Virulence Factors, Bordetella