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Article

A screen to identify cellular modulators of soluble levels of an amyotrophic lateral sclerosis (ALS)-causing mutant SOD1.

Journal of biomolecular screening - 1 Oct 2011

Somalinga Balajee R, Miller Gregory A, Malik Hiba T, Wigley W Christian, Thomas Philip J

Abstract excerpt

The molecular pathology of many protein misfolding, toxic gain-of-function diseases, such as amyotrophic lateral sclerosis (ALS), is not well understood. Although protein misfolding and aggregation are common themes in these diseases, efforts to identify cellular factors that regulate this process in an unbiased fashion and on a global scale have been lacking. Using an adapted version of an extant β-gal-based...

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Identifiers

PMID: 21875953
DOI: 10.1177/1087057111418505
PMCID: PMC3516231

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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