Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS).

Scientific reports - 15 Jun 2024

Lambert-Smith Isabella A, Shephard Victoria K, McAlary Luke, Yerbury Justin J, Saunders Darren N

Abstract excerpt

Disrupted proteome homeostasis (proteostasis) in amyotrophic lateral sclerosis (ALS) has been a major focus of research in the past two decades. However, the proteostasis processes that become disturbed in ALS are not fully understood. Obtaining more detailed knowledge of proteostasis disruption in association with different ALS-causing mutations will improve our understanding of ALS pathophysiology and may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Protein Folding

Share to Proteostasis

Share to Superoxide Dismutase-1

Source

Open in PubMed Open full text

Identifiers

PMID: 38879591
DOI: 10.1038/s41598-024-64366-0
PMCID: PMC11180180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS).PMID 38879591Read ↗

High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS)Semantic proximity Read ↗

Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis.Semantic proximity Read ↗

Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation.Semantic proximity Read ↗

New molecular signatures defining the differential proteostasis response in ALS-resistant and -sensitive motor neuronsSemantic proximity Read ↗

Integrated Multi-Omic Data Analysis and Validation with Yeast Model Show Oxidative Phosphorylation Modulate Protein Aggregation in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Protein folding alterations in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Mitochondrial proteomic analysis of a cell line model of familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS.Semantic proximity Read ↗

Proteome Homeostasis Dysfunction: A Unifying Principle in ALS PathogenesisSemantic proximity Read ↗

Rapid profiling of disease alleles using a tunable reporter of protein misfolding.Semantic proximity Read ↗

Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseasesSemantic proximity Read ↗

High Throughput Screening for Neurodegeneration and Complex Disease PhenotypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.