SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS.

doi:10.1016/j.stem.2023.01.005

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SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS.

Cell stem cell - 2 Feb 2023

Linares Gabriel R, Li Yichen, Chang Wen-Hsuan, Rubin-Sigler Jasper, Mendonca Stacee, Hong Sarah, Eoh Yunsun, Guo Wenxuan, Huang Yi-Hsuan, Chang Jonathan, Tu Sharon, Dorjsuren Nomongo, Santana Manuel, Hung Shu-Ting, Yu Johnny, Perez Joscany, Chickering Michael, Cheng Tze-Yuan, Huang Chi-Chou, Lee Shih-Jong James, Deng Hao-Jen, Bach Kieu-Tram, Gray Kamden, Subramanyam Vishvak, Rosenfeld Jeffrey, Alworth Samuel V, Goodarzi Hani, Ichida Justin K

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by many diverse genetic etiologies. Although therapeutics that specifically target causal mutations may rescue individual types of ALS, such approaches cannot treat most patients since they have unknown genetic etiology. Thus, there is a critical need for therapeutic strategies that rescue multiple forms of ALS. Here, we combine...

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PMID: 36736291
DOI: 10.1016/j.stem.2023.01.005
PMCID: PMC10062011

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