Article

High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS)

2021-09-23

Abstract excerpt

Disrupted proteome homeostasis (proteostasis) in amyotrophic lateral sclerosis (ALS) has been a major focus of research in the past two decades. Yet the exact processes that normally maintain proteostasis, but that are uniquely disturbed in motor neurons expressing diverse genetic mutations, remain to be established. Obtaining a better understanding of proteostasis disruption in association with different ALS-caus...

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Literature Corpus work: b53b7655-3832-5a65-9b0e-4c1b571fc78f
DOI: 10.1101/2021.09.23.461468

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