Article
Transcriptional control of cell-cycle quiescence during C. elegans development.
Developmental biology - 15 Jan 2008
Clayton Joseph E, van den Heuvel Sander J L, Saito R Mako
Abstract excerpt
During the development of the C. elegans reproductive system, cells that give rise to the vulva, the vulval precursor cells (VPCs), remain quiescent for two larval stages before resuming cell division in the third larval stage. We have identified several transcriptional regulators that contribute to this temporary cell-cycle arrest. Mutation of lin-1 or lin-31, two downstream targets of the Receptor Tyrosine...
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