Article
Relevance of acquired T cell molecular defects in the immunopathogenesis of SLE.
Clinical immunology (Orlando, Fla.) - 1 Jun 2024
Rosetti Florencia, Madera-Salcedo Iris K, Crispín José C
Abstract excerpt
Systemic lupus erythematosus (SLE) and other autoimmune diseases are thought to develop in genetically predisposed individuals when triggered by environmental factors. This paradigm does not fully explain disease development, as it fails to consider the delay between birth and disease expression. In this review, we discuss observations described in T cells from patients with SLE that are not related to hereditary...
Topics
- Humans
- Lupus Erythematosus, Systemic
- T-Lymphocytes
- Autoimmunity
- Genetic Predisposition to Disease
- Animals
