Article
RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element.
The EMBO journal - 26 Aug 2011
Levantini Elena, Lee Sanghoon, Radomska Hanna S, Hetherington Christopher J, Alberich-Jorda Meritxell, Amabile Giovanni, Zhang Pu, Gonzalez David A, Zhang Junyan, Basseres Daniela S, Wilson Nicola K, Koschmieder Steffen, Huang Gang, Zhang Dong-Er, Ebralidze Alexander K, Bonifer Constanze, Okuno Yutaka, Gottgens Bertie, Tenen Daniel G
Abstract excerpt
The transcription factor RUNX1 is essential to establish the haematopoietic gene expression programme; however, the mechanism of how it activates transcription of haematopoietic stem cell (HSC) genes is still elusive. Here, we obtained novel insights into RUNX1 function by studying regulation of the human CD34 gene, which is expressed in HSCs. Using transgenic mice carrying human CD34 PAC constructs, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.