Article
Distal elements are critical for human CD34 expression in vivo.
Blood - 15 Dec 2002
Okuno Yutaka, Huettner Claudia S, Radomska Hanna S, Petkova Victoria, Iwasaki Hiromi, Akashi Koichi, Tenen Daniel G
Abstract excerpt
The elements regulating gene expression in hematopoietic stem cells are still poorly understood. We previously reported that a 141-kilobase (kb) human CD34 transgene confers properly regulated human CD34 expression in transgenic mice. A construct with only the human CD34 promoter and 3' enhancer region is not sufficient, suggesting that critical distal elements are necessary for expression of the human CD34 gene....
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