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Article

Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogenec-KITand amplifies cell proliferation

10 Aug 2018

Abstract excerpt

Runt-related transcription factor 1 (RUNX1) is a well-known master regulator of hematopoietic lineages but its mechanisms of action are still not fully understood. Here, we found that RUNX1 localizes on active chromatin together with Far Upstream Binding Protein 1 (FUBP1) in human B-cell precursor lymphoblasts, and that both factors interact in the same transcriptional regulatory complex. RUNX1 and FUBP1...

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PMID: 30500954
DOI: 10.1093/nar/gky756

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