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Article

High-mobility group box protein 1: a novel mediator of inflammatory-induced renal epithelial-mesenchymal transition.

American journal of nephrology - 1 Jan 2010

Lynch Julie, Nolan Stephen, Slattery Craig, Feighery Ronan, Ryan Michael P, McMorrow Tara

Abstract excerpt

BACKGROUND: high-mobility group box protein 1 (HMGB-1) is a chromatin-binding protein that bends DNA, thereby facilitating gene transcription. HMGB-1 has also been observed as an extracellular secreted protein in serum of patients with sepsis and has putative intracellular signalling effects regulating the production of interleukin-1 and tumour necrosis factor in a number of inflammatory conditions. METHODS: we...

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Identifiers

PMID: 21099216
DOI: 10.1159/000320485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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