Article
Effects of phorbol esters on an interleukin-3-dependent cell line.
Blood - 1 Jul 1990
McCubrey J A, Steelman L S, Sandlin G, Riddle R S, Ways D K
Abstract excerpt
FDC-P1 is an interleukin-3 (IL-3)-dependent cell line that ceases to proliferate in the absence of IL-3. We have isolated variant cell lines from FDC-P1 that grow in response to phorbol myristate acetate (PMA). These variant cell lines (FD/PMA) have maintained their PMA-dependency for over 1 year...
Topics
- Animals
- Cell Line
- Cell Membrane
- Cell Separation
- Culture Media
- Drug Synergism
- Gene Expression
- Hematopoietic Stem Cells
- Interleukin-3
- Lymphokines
- Phenotype
- Phorbol Esters
- Protein Kinase C
- RNA, Messenger
- Tetradecanoylphorbol Acetate
- Thymidine
- Tritium